The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2016
Filed:
Apr. 01, 2015
Applicant:
Protiva Biotherapeutics, Inc., Burnaby, CA;
Inventors:
Assignee:
Protiva Biotherapeutics, Inc., Burnaby, BC, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); A61K 47/48 (2006.01); A61K 9/127 (2006.01); A61K 9/16 (2006.01); A61K 31/713 (2006.01); B82Y 5/00 (2011.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 9/1272 (2013.01); A61K 9/1617 (2013.01); A61K 31/713 (2013.01); A61K 47/488 (2013.01); A61K 47/48053 (2013.01); A61K 47/48123 (2013.01); A61K 47/48215 (2013.01); A61K 47/48853 (2013.01); B82Y 5/00 (2013.01); C12N 2310/14 (2013.01); C12N 2310/321 (2013.01); C12N 2310/3515 (2013.01); C12N 2310/3521 (2013.01); C12N 2320/30 (2013.01);
Abstract
The present invention provides compositions comprising therapeutic nucleic acids such as interfering RNA that target apolipoprotein C-III (APOC3) gene expression, lipid particles comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles (e.g., for the treatment of lipid diseases or disorders such as atherosclerosis or a dyslipidemia such as hypertriglyceridemia or hypercholesterolemia).