The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2016
Filed:
Dec. 31, 2013
Development Center for Biotechnology, New Taipei, TW;
Dcb-usa Llc, Wilmington, New Castle, DE (US);
Jiann-Shiun Lai, New Taipei, TW;
Hung-Ling Wang, New Taipei, TW;
Chao-Yang Huang, New Taipei, TW;
Ying-Yung Lok, New Taipei, TW;
Yuan-Tsong Chen, New Taipei, TW;
Woan-Eng Chan, New Taipei, TW;
Chih-Yung Hu, New Taipei, TW;
Development Center for Biotechnology, New Taipei, TW;
DCB-USA LLC, Wilmington, DE (US);
Academia Sinica, Taipei, TW;
Abstract
An anti-granulysin antibody, or an scFv or Fab fragment thereof, capable of binding to an epitope region from R64 to R113 of granulysin and capable of neutralizing an activity of granulysin. The antibody may contain a sequence selected from the sequences of SEQ ID NO:82 to SEQ ID NO:195, or the antibody may contain a sequence selected from the sequences of SEQ ID NO:39 to SEQ ID NO:76. The antibody may be a monoclonal antibody. A method for treating or preventing an unwanted immune response disorder includes administering to a subject in need thereof an effective amount of an anti-granulysin antibody capable of neutralizing the activity of granulysin. The unwanted immune response disorder may be SJS, TEN, or GVHD.