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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9428573 B1

PDFFull Text
Date of Patent:
Aug. 30, 2016

Filed:

Jul. 19, 2013

Multimeric il-15 soluble fusion molecules and methods of making and using same

Applicant:

Altor Bioscience Corporation, Miramar, FL (US);

Inventors:

Hing C. Wong, Weston, FL (US);

Peter Rhode, Miami, FL (US);

Bai Liu, Cooper City, FL (US);

Xiaoyun Zhu, Miami, FL (US);

Kai-ping Han, Miramar, FL (US);

Assignee:

Altor Bioscience Corporation, Miramar, FL (US);

Attorneys:

Mintz Levin Cohn Ferris Glovsky and Popeo, P.C.

Peter F. Corless, Esq.

Daniel W. Clarke

Primary Examiner:

Bridget E Bunner

Assistant Examiner:

Fozia Hamud

Int. Cl.
CPC ...
C07K 14/54 (2006.01); C07K 14/705 (2006.01); C07K 19/00 (2006.01); C07K 16/18 (2006.01); C12N 15/62 (2006.01); C12N 15/09 (2006.01); C12P 21/00 (2006.01); C07K 14/715 (2006.01); A61K 38/20 (2006.01); C07K 14/435 (2006.01); C07K 14/47 (2006.01); C07K 16/24 (2006.01); C12N 15/24 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/18 (2013.01); A61K 38/2086 (2013.01); C07K 14/5443 (2013.01); C07K 14/7155 (2013.01); C12N 15/09 (2013.01); C12N 15/62 (2013.01); C12P 21/00 (2013.01); A61K 38/00 (2013.01); C07K 2319/21 (2013.01); C07K 2319/22 (2013.01); C07K 2319/30 (2013.01);
Abstract

The invention provides soluble fusion protein complexes having at least two soluble fusion proteins. The first fusion protein is a biologically active polypeptide covalently linked to an interleukin-15 (IL-15) polypeptide or a functional fragment thereof. The second fusion protein is a second biologically active polypeptide covalently linked to a soluble interleukin-15 receptor alpha (IL-15Rα) polypeptide or a functional fragment thereof. In the complexes of the invention, one or both of the first and second fusion proteins further includes an immunoglobulin Fc domain or a functional fragment thereof; and the first fusion protein binds to the soluble IL-15Rα domain of the second fusion protein to form a soluble fusion protein complex. The invention further provides methods for making and using the complexes of the invention.

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