The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2016
Filed:
Oct. 03, 2012
Applicant:
Moderna Therapeutics, Cambridge, MA (US);
Inventors:
Antonin de Fougerolles, Brookline, MA (US);
Atanu Roy, Stoneham, MA (US);
Jason P. Schrum, Philadelphia, PA (US);
Suhaib Siddiqi, Burlington, MA (US);
Paul Hatala, Charlestown, MA (US);
Stephane Bancel, Boston, MA (US);
Assignee:
Moderna Therapeutics, Inc., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C07H 21/02 (2006.01); C12N 15/67 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C07H 21/02 (2013.01); C12N 15/11 (2013.01); C12N 15/67 (2013.01); A61K 48/0066 (2013.01);
Abstract
The present disclosure provides methods of increasing the level of a polypeptide of interest in a mammalian subject by administering a polynucleotide having one or more chemical modifications and a Protein:Cytokine ratio of greater than 100.