The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 30, 2016

Filed:

May. 05, 2015
Applicant:

Astrazeneca Ab, Södertälje, SE;

Inventors:

Bernard Christophe Barlaam, Cheshire, GB;

Kurt Gordon Pike, Cheshire, GB;

Assignee:

AstraZeneca AB, Sodertalje, SE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61K 31/4745 (2006.01); A61K 31/444 (2006.01); A61K 45/06 (2006.01); A61K 31/4545 (2006.01); A61K 31/502 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/444 (2013.01); A61K 31/4545 (2013.01); A61K 31/4745 (2013.01); A61K 31/502 (2013.01); A61K 45/06 (2013.01);
Abstract

The specification generally relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof, where Q, R, R, R, Rand Rhave any of the meanings defined herein. The specification also relates to the use of such compounds and salts thereof to treat or prevent ATM kinase mediated disease, including cancer. The specification further relates to crystalline forms of compounds of imidazo[4,5-c]quinolin-2-one compounds and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds and salts; kits comprising such compounds and salts; methods of manufacture of such compounds and salts; intermediates useful in the manufacture of such compounds and salts; and to methods of treating ATM kinase mediated disease, including cancer, using such compounds and salts.


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