The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2016
Filed:
Dec. 16, 2011
Raffaella Rossin, Eindhoven, NL;
Tilman Laeppchen, Eindhoven, NL;
Sandra Martina Van Den Bosch, Weert, NL;
Marc Stefan Robillard, Eindhoven, NL;
Ronny Mathieu Versteegen, Hegelsom, NL;
Raffaella Rossin, Eindhoven, NL;
Tilman Laeppchen, Eindhoven, NL;
Sandra Martina Van Den Bosch, Weert, NL;
Marc Stefan Robillard, Eindhoven, NL;
Ronny Mathieu Versteegen, Hegelsom, NL;
KONINKLIJKE PHILIPS N.V., Eindhoven, NL;
Abstract
Described is a method, and a combination of agents for used therein, by which an agent administered to a subject can be rapidly cleared from circulation. This is achieved by providing an Administration Agent (e.g. a probe for pretargeting) with a reactive group and providing a Clearing Agent with another reactive group, said reactive groups forming a bio-orthogonally reactive pair. Preferably, the reactive pair comprises a cyclooctene or cyclooctyn as one reactant, and a diene as the other reactant. The method and combination can be used for the removal of any bindable molecule from circulation, such as an excess of a pre-targeting probe in the course of a pre-targeting method, a targeting or imaging agent delivered, or the removal of any biomolecule already present in circulation.