The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2016
Filed:
Aug. 07, 2008
Applicants:
Ambrose Cheung, Hanover, NH (US);
Guido Memmi, White River Junction, VT (US);
Inventors:
Ambrose Cheung, Hanover, NH (US);
Guido Memmi, White River Junction, VT (US);
Assignee:
TRUSTEES OF DARTMOUTH COLLEGE, Hanover, NH (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/545 (2006.01); A61K 31/43 (2006.01); A01N 37/18 (2006.01); A61K 38/04 (2006.01); A61K 45/06 (2006.01); A61K 31/546 (2006.01); C12Q 1/18 (2006.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
A61K 45/06 (2013.01); A61K 31/546 (2013.01); C12Q 1/18 (2013.01); C12Q 1/689 (2013.01); G01N 2333/31 (2013.01);
Abstract
The present invention includes compositions and methods for diagnosing and treating CA-MRSA infections in patients. The methods are based on the finding that combining cefoxitin and a synthetic penicillin in a treatment regimen results in a synergistic effect of the two drugs, an effect that is related to PBP4 activity in CA-MRSA isolates. Also provided is a CA-MRSA-specific biomarker which can be used to detect the presence of a CA-MRSA infection in a patient.