The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2016
Filed:
Jun. 25, 2010
Applicants:
Yang Liu, Ann Arbor, MI (US);
Yin Wang, Ann Arbor, MI (US);
Yan Liu, Ann Arbor, MI (US);
Sami N. Malek, Ann Arbor, MI (US);
Pan Zheng, Ann Arbor, MI (US);
Inventors:
Yang Liu, Ann Arbor, MI (US);
Yin Wang, Ann Arbor, MI (US);
Yan Liu, Ann Arbor, MI (US);
Sami N. Malek, Ann Arbor, MI (US);
Pan Zheng, Ann Arbor, MI (US);
Assignee:
OncoImmune, Inc., Rockville, MD (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/00 (2006.01); A61K 31/33 (2006.01); A61K 31/00 (2006.01); A61K 31/395 (2006.01); A61K 31/498 (2006.01); A61K 31/565 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/00 (2013.01); A61K 31/395 (2013.01); A61K 31/498 (2013.01); A61K 31/565 (2013.01); A61K 45/06 (2013.01);
Abstract
The present invention relates to treating a hematologic cancer using a Hypoxia-Inducible Factor (HIF inhibitor). The invention also relates to inducing acute myeloid leukemia remission using the HIF inhibitor. The invention further relates to inhibiting a maintenance or survival function of a cancer stem cell (CSC) using the HIF inhibitor.