The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2016
Filed:
Jun. 11, 2010
Applicants:
Peter Hahn, Bergisch Gladbach, DE;
Eric Lader, Boyds, MD (US);
Wolfgang Bielke, Mechemich, DE;
Alexander Azzawi, Solingen, DE;
Jie Kang, Hann, DE;
Inventors:
Peter Hahn, Bergisch Gladbach, DE;
Eric Lader, Boyds, MD (US);
Wolfgang Bielke, Mechemich, DE;
Alexander Azzawi, Solingen, DE;
Jie Kang, Hann, DE;
Assignee:
QIAGEN GMBH, Hilden, GB;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C07H 21/04 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
C12N 15/111 (2013.01); C12N 15/113 (2013.01); C12N 2310/14 (2013.01); C12N 2310/332 (2013.01); C12N 2320/51 (2013.01);
Abstract
The present invention pertains to the use of at least one abasic modification within the first 8 nucleotide positions of the 5' region of the antisense strand of a small interfering nucleic acid (siNA) molecule for reducing off-target effects. Provided are suitable modified siNAs, compositions and methods for producing respective siNAs, as well as kits comprising respective siNAs.