The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2016
Filed:
Jul. 29, 2011
Grace Chen, Cambridge, MA (US);
Fabio Fachin, Cambridge, MA (US);
Mehmet Toner, Wellesley, MA (US);
Brian Wardle, Lexington, MA (US);
Grace Chen, Cambridge, MA (US);
Fabio Fachin, Cambridge, MA (US);
Mehmet Toner, Wellesley, MA (US);
Brian Wardle, Lexington, MA (US);
The General Hospital Corporation, Boston, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
Abstract
The devices and systems described herein include one or more fluid paths, e.g., channels, and one or more selectively permeable obstacles arranged in the fluid path(s), each including a plurality of aligned nanostructures, e.g., nanotubes or nanorods, defining an outer surface of the obstacle and an internal network of voids. The obstacle(s) can further include binding moieties applied to the outer surface and/or to the surfaces of the individual nanostructures within the obstacle(s). The devices can be manufactured by forming the dense groupings of nanostructures to extend outwards and upwards from a substrate; forming a fluidic channel, bonding the fluidic channel to the substrate; and optionally applying binding moieties to the obstacles. The devices can be used to manipulate cells within fluid samples.