The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 23, 2016

Filed:

Nov. 26, 2013
Applicant:

Morphotek, Inc., Exton, PA (US);

Inventors:

Philip M. Sass, Audubon, PA (US);

Nicholas C. Nicolaides, Glen Mills, PA (US);

Luigi Grasso, Bryn Mawr, PA (US);

Jian Li, Fort Washington, PA (US);

Qimin Chao, Havertown, PA (US);

Eric Routhier, Glen Mills, PA (US);

Wolfgang Ebel, Plymouth Meeting, PA (US);

Assignee:

Morphotek, Inc., Exton, PA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/22 (2006.01); C12P 21/08 (2006.01); C07K 16/24 (2006.01); C07K 16/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/243 (2013.01); A61K 39/395 (2013.01); A61K 39/3955 (2013.01); C07K 16/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/21 (2013.01); C07K 2317/34 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/73 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01);
Abstract

Hybridoma lines that secrete human monoclonal antibodies with high binding specificity and biological activity, particularly neutralizing activity against granulocyte-macrophage colony stimulating factor, and methods of generating the hybridoma lines are provided. Target antigens and epitopes are also provided. The antibodies may be used in therapeutic methods, for example in the treatment of cancer, infectious disease, or autoimmune disease.


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