The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2016
Filed:
Jul. 12, 2007
Raul Rabadan, Princeton, NJ (US);
Michael Krasnitz, Princeton, NJ (US);
Harlan Robins, Seattle, WA (US);
Daniela Witten, Princeton, NJ (US);
Arnold Levine, Doylestown, PA (US);
Raul Rabadan, Princeton, NJ (US);
Michael Krasnitz, Princeton, NJ (US);
Harlan Robins, Seattle, WA (US);
Daniela Witten, Princeton, NJ (US);
Arnold Levine, Doylestown, PA (US);
Institute of Advanced Study, Princeton, NJ (US);
Abstract
The invention relates to inhibitory nucleotide signal sequences or 'INS' sequences in the genomes of lentiviruses. In particular the invention relates to the AGG motif present in all viral genomes. The AGG motif may have an inhibitory effect on a virus, for example by reducing the levels of, or maintaining low steady-state levels of, viral RNAs in host cells, and inducing and/or maintaining in viral latency. In one aspect, the invention provides vaccines that contain, or are produced from, viral nucleic acids in which the AGG sequences have been mutated. In another aspect, the invention provides methods and compositions for affecting the function of the AGG motif, and methods for identifying other INS sequences in viral genomes.