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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9422309 B1

PDFFull Text
Date of Patent:
Aug. 23, 2016

Filed:

Jun. 21, 2013

3-o-heteroaryl-ingenol

Applicant:

Leo Laboratories Limited, Dublin, IE;

Inventors:

Xifu Liang, Ballerup, DK;

Thomas Högberg, Ballerup, DK;

Bjarne Nørremark, Ballerup, DK;

Kristoffer Månsson, Ballerup, DK;

Carsten Ryttersgaard, Ballerup, DK;

Gunnar Grue-Sørensen, Roskilde, DK;

Assignee:

LEO LABORATORIES LIMITED, Dublin, IE;

Attorney:

Birch, Stewart, Kolasch & Birch, LLP

Primary Examiner:

Samantha Shterengarts

Int. Cl.
CPC ...
C07D 495/04 (2006.01); A61K 31/4164 (2006.01); A61K 31/416 (2006.01); A61K 31/4245 (2006.01); A61K 31/4355 (2006.01); A61K 31/44 (2006.01); A61K 31/47 (2006.01); A61K 31/506 (2006.01); C07D 213/84 (2006.01); C07D 215/22 (2006.01); C07D 231/56 (2006.01); C07D 233/70 (2006.01); C07D 239/34 (2006.01); C07D 261/20 (2006.01); C07D 491/00 (2006.01); C07D 271/06 (2006.01); C07D 495/00 (2006.01); C07D 213/64 (2006.01); A61K 45/06 (2006.01); A61K 31/472 (2006.01); A61K 31/505 (2006.01); A61K 8/49 (2006.01); A61K 31/42 (2006.01); A61K 31/423 (2006.01); A61K 31/4365 (2006.01); A61Q 19/08 (2006.01); C07D 217/24 (2006.01); C07D 271/07 (2006.01); C07D 491/048 (2006.01);
U.S. Cl.
CPC ...
C07D 495/04 (2013.01); A61K 8/49 (2013.01); A61K 8/4926 (2013.01); A61K 8/4946 (2013.01); A61K 8/4953 (2013.01); A61K 31/416 (2013.01); A61K 31/4164 (2013.01); A61K 31/42 (2013.01); A61K 31/423 (2013.01); A61K 31/4245 (2013.01); A61K 31/4355 (2013.01); A61K 31/4365 (2013.01); A61K 31/44 (2013.01); A61K 31/47 (2013.01); A61K 31/472 (2013.01); A61K 31/505 (2013.01); A61K 31/506 (2013.01); A61K 45/06 (2013.01); A61Q 19/08 (2013.01); C07D 213/64 (2013.01); C07D 213/84 (2013.01); C07D 215/22 (2013.01); C07D 217/24 (2013.01); C07D 231/56 (2013.01); C07D 233/70 (2013.01); C07D 239/34 (2013.01); C07D 261/20 (2013.01); C07D 271/06 (2013.01); C07D 271/07 (2013.01); C07D 491/00 (2013.01); C07D 491/048 (2013.01); C07D 495/00 (2013.01);
Abstract

The present invention relates to a compound according to formula (I) wherein Rrepresents optionally substituted heteroaryl, and pharmaceutically acceptable salts, hydrates, solvates or pharmaceutically acceptable and physiologically cleavable esters thereof. The invention relates further to intermediates for the preparation of said compounds, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g. diseases associated with hyperplasia, neoplasia or dysplasia, with said compounds, to methods of treatment of cosmetic indications with said compounds, and to the use of said compounds in the manufacture of medicaments.

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