The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 23, 2016

Filed:

Aug. 07, 2015
Applicant:

Molecular Insight Pharmaceuticals, Inc., Tarrytown, NY (US);

Inventors:

John W. Babich, Cambridge, MA (US);

Craig Zimmerman, Topsfield, MA (US);

John L. Joyal, Melrose, MA (US);

Genliang Lu, Winchester, MA (US);

Shawn Hillier, Danvers, MA (US);

Kevin P. Maresca, Tewksbury, MA (US);

John Marquis, Nashua, NH (US);

Assignee:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 51/00 (2006.01); A61M 36/14 (2006.01); C07D 249/04 (2006.01); C07D 403/12 (2006.01); C07F 13/00 (2006.01); C07D 233/64 (2006.01); C07D 417/12 (2006.01); C07D 233/00 (2006.01); A61K 51/04 (2006.01);
U.S. Cl.
CPC ...
C07D 249/04 (2013.01); A61K 51/0478 (2013.01); C07D 233/64 (2013.01); C07D 403/12 (2013.01); C07D 417/12 (2013.01); C07F 13/00 (2013.01); C07F 13/005 (2013.01); A61K 51/0453 (2013.01); C07D 233/00 (2013.01);
Abstract

A ligand, a pharmaceutically acceptable salt, tautomer, or ester thereof, may be represented as: In the formula, X is selected from the group consisting of —(CH)—, —(CH)—O—, —(CH)—N(R)—, —(CH)—N(R)—C(O)— and —O—; Ris hydrogen or (C-C)alkyl; G is —(CH(R))—R—, or —(CH)—C(O)—R; G' is —(CH(R))—R—, or —(CH)—C(O)—R; Ris —H, —OH, NRR, or —COH; Ris —H, —COOH, or substituted or unsubstituted —COO(C-C)alkyl; Rand Rare each independently H, substituted or unsubstituted (C-C)alkyl, or substituted or unsubstituted carboxy(C-C)alkylene; m is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10; n is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10; and p is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.


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