The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2016
Filed:
Nov. 26, 2008
Sachin S. Chandran, Highland Park, NJ (US);
Sangeeta Ray, Ellicott City, MD (US);
Martin G. Pomper, Baltimore, MD (US);
Samuel R. Denmeade, Ellicott City, MD (US);
Ronnie C. Mease, Fairfax, VA (US);
Sachin S. Chandran, Highland Park, NJ (US);
Sangeeta Ray, Ellicott City, MD (US);
Martin G. Pomper, Baltimore, MD (US);
Samuel R. Denmeade, Ellicott City, MD (US);
Ronnie C. Mease, Fairfax, VA (US);
The Johns Hopkins University, Baltimore, MD (US);
Abstract
The invention provides a nanoparticle composition that is decorated with a urea-based small-molecule peptidomimetic inhibitor of prostate specific membrane antigen (PSMA), which is expressed by almost all solid tumors. This strategy takes advantage of both the avidity of the functionalized nanoparticle for binding to PSMA and the ability of the nanoparticle to be retained for longer periods of time in the tumor due to enhanced leakage via EPR into the tumor interstitium and poor clearance due to underdeveloped or non-existent lymphatics within the tumor.