The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2016
Filed:
Mar. 16, 2012
Jeffrey D. Laskin, Piscataway, NJ (US);
Ned D. Heindel, Easton, PA (US);
Carl Jeffrey Lacey, Schnecksville, PA (US);
Abhilash N. Pillai, Tiruvalla, IN;
Marion Gordon, Princeton, NJ (US);
Diane E. Heck, Rumson, NJ (US);
Jeffrey D. Laskin, Piscataway, NJ (US);
Ned D. Heindel, Easton, PA (US);
Carl Jeffrey Lacey, Schnecksville, PA (US);
Abhilash N. Pillai, Tiruvalla, IN;
Marion Gordon, Princeton, NJ (US);
Diane E. Heck, Rumson, NJ (US);
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, New Brunswick, NJ (US);
LEHIGH UNIVERSITY, Bethlehem, PA (US);
Abstract
Three unique subtypes of N-hydroxyamides and N-hydroxycarbamates containing both the vanilloid moiety (4-hydroxy-3-methoxybenzyl) and a lipophilic aliphatic moiety. Also disclosed are direct syntheses of these vanilloid fatty hydroxamates. The compounds possess inhibitory activity against the enzymes fatty acid amide hydrolase (FAAH) and matrix metallo-proteinase 9 (MMP-9). In addition, these substances bind to the calcium channel protein TRPV1 and inhibit vesicant-induced inflammation in skin and cornea. The compounds have utility in treating topical or systemic inflammatory processes in the skin and/or eye.