The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2016
Filed:
Jun. 08, 2012
Applicants:
John Guzowski, Melrose, MA (US);
William Kiesman, Wayland, MA (US);
Erwin Irdham, Melrose, MA (US);
Inventors:
Assignee:
Biogen MA Inc., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 67/297 (2006.01); C07C 67/52 (2006.01); C07C 67/08 (2006.01); C07C 69/60 (2006.01); C07C 69/604 (2006.01);
U.S. Cl.
CPC ...
C07C 67/52 (2013.01); C07C 67/08 (2013.01); C07C 67/297 (2013.01); C07C 69/60 (2013.01); C07C 69/604 (2013.01); C07B 2200/13 (2013.01);
Abstract
The present invention describes a process for the preparation of dimethyl fumarate. The process involves the esterification of fumaric acid and methanol in the presence of sulfuric acid as an acid catalyst. The high purity dimethyl fumarate contains no more than trace amounts of dimethyl sulfate. The present invention also provides a process for the preparation of highly pure dimethyl fumarate with a particle size from 20 to 250μπι.