The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2016
Filed:
Feb. 07, 2013
The Trustees of Columbia University IN the City of New York, New York, NY (US);
Hong Jiang, Fort Lee, NJ (US);
Leonard Chess, Scarsdale, NY (US);
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK, New York, NY (US);
Abstract
Methods are provided for inhibiting or enhancing down-regulation of an antigen-activated HLA-ET cell by an HLA-E-restricted CD8T cell comprising contacting the HLA-ET cell and CD8T cell with an agent which inhibits or enhances, respectively, binding between (i) T cell receptor (TCR) on the surface of the CD8T cell and (ii) a self peptide presented by HLA-E on the surface of the HLA-ET cell, thereby inhibiting or enhancing, respectively, down-regulation of the antigen-activated HLA-ET cell. Compositions comprising agents which inhibit or enhance/activate, respectively, binding between (i) T cell receptor (TCR) on the surface of a CD8T cell and (ii) a self peptide presented by HLA-E on the surface of a HLA-ET cell, and assays for identifying such agents, are provided.