The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2016
Filed:
Jul. 28, 2014
Applicant:
Case Western Reserve University, Cleveland, OH (US);
Inventors:
Kurt Q. Lu, Cleveland Heights, OH (US);
Kevin D. Cooper, Moreland Hills, OH (US);
Assignee:
Case Western Reserve University, Cleveland, OH (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4439 (2006.01); A61K 39/395 (2006.01); A61K 38/00 (2006.01); A61K 45/06 (2006.01); A61K 31/426 (2006.01); C12N 5/0786 (2010.01);
U.S. Cl.
CPC ...
A61K 31/4439 (2013.01); A61K 31/426 (2013.01); A61K 38/00 (2013.01); A61K 39/3955 (2013.01); A61K 39/39533 (2013.01); A61K 45/06 (2013.01); C12N 5/0645 (2013.01); C12N 2500/36 (2013.01); C12N 2501/23 (2013.01); C12N 2501/385 (2013.01);
Abstract
A method of generating a hyper iNOS expressing cell includes administering to a myeloid derived cell an amount of a PPARγ agonist and an IL-6/STAT3 signaling pathway antagonist effective to substantially inhibit STAT3 activation in the cell and administering an inflammatory insult to the cell to stimulate hyper iNOS expression from the cell.