The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 16, 2016
Filed:
Jun. 27, 2012
Shinichi Yoshida, Takasago, JP;
Shunichi Taira, Takasago, JP;
Masakatsu Nishihachijyo, Takasago, JP;
Masutoshi Nojiri, Takasago, JP;
Shigeru Kawano, Takasago, JP;
Shinichi Yoshida, Takasago, JP;
Shunichi Taira, Takasago, JP;
Masakatsu Nishihachijyo, Takasago, JP;
Masutoshi Nojiri, Takasago, JP;
Shigeru Kawano, Takasago, JP;
KANEKA CORPORATION, Osaka, JP;
Abstract
An object of the present invention is to provide a method for converting the coenzyme dependency of enzymes of the medium-chain dehydrogenase/reductase (MDR) family. A further object of the present invention is to provide enzyme variants of the MDR family whose coenzyme dependency is converted by the conversion method and a method for enzymatically producing optically active alcohols using the enzymes. The present inventors developed a novel enzyme conversion method for converting the coenzyme dependency of enzymes of the MDR family, rationally designed enzyme variants that are altered by the enzyme conversion method to be able to use NADPH as a coenzyme from a useful enzyme of the MDR family that uses NADH as a coenzyme, and actually provide variants having such an ability.