The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 16, 2016

Filed:

Aug. 29, 2014
Applicant:

The Asan Foundation, Seoul, KR;

Inventors:

Jae Kwan Song, Seoul, KR;

Eun Ju Chang, Seoul, KR;

Mi Jeong Kim, Incheon, KR;

Bongkun Choi, Gyeonggi-do, KR;

Sahmin Lee, Seoul, KR;

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/70 (2006.01); C07K 16/44 (2006.01); A61K 31/4985 (2006.01); A61K 31/7105 (2006.01); A61K 31/713 (2006.01); A61K 38/06 (2006.01); C12N 5/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/44 (2013.01); A61K 31/4985 (2013.01); A61K 31/713 (2013.01); A61K 31/7105 (2013.01); A61K 38/06 (2013.01); C12Y 304/14005 (2013.01);
Abstract

There is provided a composition for prophylaxis or treatment of vascular or valvular calcification including a dipeptidylpeptidase-4 (DPP-4) inhibitor. The DPP-4 according to one exemplary embodiment of the present disclosure is expressed at an increased level when blood vessels and valves are calcified, and the calcification decreases remarkably upon administration of the DPP-4 inhibitor. Therefore, the DPP-4 inhibitor can be useful in treatment or prophylaxis of blood vessels or valves.


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