The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 16, 2016
Filed:
May. 06, 2014
Applicant:
Abbvie Inc., North Chicago, IL (US);
Inventors:
Min Wang, Shrewsbury, MA (US);
Patrick M. Hossler, Westborough, MA (US);
Sean W. McDermott, Warwick, RI (US);
Christopher Racicot, Auburn, MA (US);
Kofi Chemfe, Worcester, MA (US);
John Fann, Shrewsbury, MA (US);
Assignee:
AbbVie Inc., North Chicago, IL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C07K 16/24 (2006.01); A61K 39/395 (2006.01); C07K 16/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/241 (2013.01); A61K 39/39591 (2013.01); C07K 16/00 (2013.01); C12N 5/005 (2013.01); C12N 5/0043 (2013.01); C07K 2317/14 (2013.01); C12N 2501/999 (2013.01); C12N 2510/02 (2013.01);
Abstract
Supplementation of the bioflavonoids such as epigallocatechin gallate, rutin, naringin, or genistein into mammalian cell culture media are shown to be effective in reduction of acidic species variants on recombinant antibodies. The demonstrated reduction in acidic species through the use of bioflavonoids, facilitates the manufacturing of a less heterogeneous product with potential improvements in antibody structure and function.