The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 16, 2016
Filed:
Dec. 16, 2014
Oncomed Pharmaceuticals, Inc., Redwood City, CA (US);
Austin L. Gurney, San Francisco, CA (US);
Timothy Charles Hoey, Hillsborough, CA (US);
Aaron Ken Sato, Burlingame, CA (US);
Alexandra Lazetic, San Jose, CA (US);
Zhimin Ji, Palo Alto, CA (US);
OncoMed Pharmaceuticals, Inc., Redwood City, CA (US);
Abstract
The present invention relates to Jagged-binding agents and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind to an extracellular domain of human Jagged1 or human Jagged2 and modulate Jagged activity. The present invention further provides methods of using agents that modulate the activity of Jagged, such as antibodies that specifically bind Jagged, and inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.