The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 16, 2016

Filed:

Feb. 27, 2014
Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Michael Miller, Scotch Plains, NJ (US);

Kallol Basu, Hillsborough, NJ (US);

Duane DeMong, Somerset, NJ (US);

Jack Scott, Scotch Plains, NJ (US);

Wei Li, Audubon, PA (US);

Joel Harris, Blaine, MN (US);

Andrew Stamford, Chatham, NJ (US);

Marc Poirier, Stewartsville, NJ (US);

Paul Tempest, Shanghai, CN;

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/505 (2006.01); C07D 403/14 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 409/14 (2006.01); C07D 417/14 (2006.01); A61K 31/506 (2006.01); C07D 471/10 (2006.01); C07D 491/107 (2006.01); C07D 498/08 (2006.01); C07D 403/04 (2006.01);
U.S. Cl.
CPC ...
C07D 403/14 (2013.01); A61K 31/506 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/10 (2013.01); C07D 491/107 (2013.01); C07D 498/08 (2013.01); A61K 31/505 (2013.01); C07D 403/04 (2013.01);
Abstract

The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.


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