The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 16, 2016
Filed:
Nov. 08, 2013
Applicant:
Massachusetts Institute of Technology, Cambridge, MA (US);
Inventors:
Darrell J. Irvine, Arlington, MA (US);
Bruce D. Walker, Nahant, MA (US);
Richard Bradley Jones, Toronto, CA;
Assignees:
Massachusetts Institute of Technology, Cambridge, MA (US);
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 35/14 (2015.01); A61K 35/17 (2015.01); A61K 38/20 (2006.01); A61K 47/48 (2006.01); A61K 31/167 (2006.01); A61K 31/27 (2006.01); A61K 31/4045 (2006.01); A61K 31/4406 (2006.01); A61K 31/7068 (2006.01); A61K 31/506 (2006.01); A61K 31/675 (2006.01); A61K 45/06 (2006.01); A61K 31/215 (2006.01); A61K 9/127 (2006.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); A61K 31/167 (2013.01); A61K 31/215 (2013.01); A61K 31/27 (2013.01); A61K 31/4045 (2013.01); A61K 31/4406 (2013.01); A61K 31/506 (2013.01); A61K 31/675 (2013.01); A61K 31/7068 (2013.01); A61K 38/2086 (2013.01); A61K 45/06 (2013.01); A61K 47/48776 (2013.01); A61K 47/48815 (2013.01); A61K 47/48884 (2013.01); A61K 47/48907 (2013.01); A61K 47/48915 (2013.01); A61K 9/127 (2013.01);
Abstract
The invention provides compositions and methods for delivering an agent to virally infected tissues and/or cells of a subject by conjugating agent-loaded nanoparticles to virus-specific T cells, such as cytotoxic T lymphocytes. The agent may be a latency-reversing drug (LRD), an antiviral agent and/or an agent that enhances cytotoxic efficacy of T lymphocytes.