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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9415040 B1

PDFFull Text
Date of Patent:
Aug. 16, 2016

Filed:

May. 08, 2015

Inhibition of quorum sensing-mediated processes in bacteria

Applicant:

The Trustees of Princeton University, Princeton, NJ (US);

Inventors:

Bonnie Bassler, Princeton, NJ (US);

Lee Swem, San Carlos, CA (US);

Assignee:

The Trustees of Princeton University, Princeton, NJ (US);

Attorney:

Meagher Emanuel Laks Goldberg & Liao, LLP

Primary Examiner:

Joseph Kosack

Int. Cl.
CPC ...
A01N 41/10 (2006.01); A01N 43/28 (2006.01); A01N 43/52 (2006.01); A01N 43/653 (2006.01); A01N 43/78 (2006.01); A01N 43/82 (2006.01); A01N 43/90 (2006.01); C07D 471/04 (2006.01); A61K 31/40 (2006.01); C07C 317/24 (2006.01); C07D 235/28 (2006.01); C07D 249/12 (2006.01); C07D 277/42 (2006.01); C07D 285/14 (2006.01); C07D 327/04 (2006.01); A61K 31/454 (2006.01); A61K 31/122 (2006.01); A61K 31/165 (2006.01); A61K 31/381 (2006.01); A61K 31/404 (2006.01); A61K 31/4184 (2006.01); A61K 31/4196 (2006.01); A61K 31/426 (2006.01); A61K 31/428 (2006.01); A61K 31/433 (2006.01); A61K 31/437 (2006.01);
U.S. Cl.
CPC ...
A61K 31/454 (2013.01); A01N 41/10 (2013.01); A01N 43/28 (2013.01); A01N 43/52 (2013.01); A01N 43/653 (2013.01); A01N 43/78 (2013.01); A01N 43/82 (2013.01); A01N 43/90 (2013.01); A61K 31/122 (2013.01); A61K 31/165 (2013.01); A61K 31/381 (2013.01); A61K 31/40 (2013.01); A61K 31/404 (2013.01); A61K 31/4184 (2013.01); A61K 31/4196 (2013.01); A61K 31/426 (2013.01); A61K 31/428 (2013.01); A61K 31/433 (2013.01); A61K 31/437 (2013.01); C07C 317/24 (2013.01); C07D 235/28 (2013.01); C07D 249/12 (2013.01); C07D 277/42 (2013.01); C07D 285/14 (2013.01); C07D 327/04 (2013.01); C07D 471/04 (2013.01);
Abstract

Methods are provided for identifying molecules that can be used to positively and negatively manipulate quorum-sensing-mediated communication to control bacterial behavior. Small-molecule antagonists that disrupt quorum-sensing-mediated activities are identified. Methods are provided for disrupting detection of acyl-homoserine lactone autoinducer in Gram-negative bacteria by contacting the bacteria with the antagonists. Methods of inhibiting quorum sensing-mediated activity in Gram-negative bacteria are provided wherein the activity is pathogenicity, bioluminescence, siderophore production, type III secretion, or metalloprotease production.

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