The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2016
Filed:
Sep. 15, 2015
Applicants:
National Tsing Hua University, Hsinchu, TW;
China Medical University, Taichung, TW;
Inventors:
Assignees:
National Tsing Hua University, Hsinchu, TW;
China Medical University, Taichung, TW;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 16/34 (2006.01); A61P 25/28 (2006.01); G01N 33/68 (2006.01); A61K 31/428 (2006.01); C07K 16/18 (2006.01); G01N 33/564 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6896 (2013.01); A61K 31/428 (2013.01); C07K 16/18 (2013.01); G01N 33/564 (2013.01); G01N 33/6854 (2013.01); G01N 33/6893 (2013.01); G01N 2800/28 (2013.01); G01N 2800/285 (2013.01);
Abstract
The present invention provides a method of determining and treating amyotrophic lateral sclerosis (ALS) in a subject, comprising the following steps: (1) measuring a concentration of an autoantibody against high mobility group box 1 protein (HMGB1) in a biological sample from the subject; and (2) administering an effective amount of ALS-treating drug to the subject whose measured concentration of the autoantibody against HMGB1 is higher than 0.874 μg/ml.