The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2016
Filed:
Feb. 22, 2012
Applicant:
Tariq M. Rana, San Diego, CA (US);
Inventor:
Tariq M. Rana, San Diego, CA (US);
Assignee:
Sanford-Burnham Medical Research Institute, La Jolla, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); C12N 5/06 (2006.01); C12N 5/08 (2006.01); C07H 21/04 (2006.01); C12N 5/074 (2010.01); G01N 33/50 (2006.01); C07H 21/02 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0696 (2013.01); G01N 33/5073 (2013.01); C07H 21/02 (2013.01); C07H 21/04 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01); C12N 2310/141 (2013.01); C12N 2501/415 (2013.01); C12N 2501/60 (2013.01); C12N 2501/602 (2013.01); C12N 2501/603 (2013.01); C12N 2501/604 (2013.01); C12N 2501/606 (2013.01); C12N 2501/998 (2013.01); C12N 2503/02 (2013.01); C12N 2506/00 (2013.01); C12N 2506/1307 (2013.01);
Abstract
The present invention is based on the seminal concept of combining genomics and chemical biology to identify new agents useful for induced pluripotent stem cell (iPSC) generation. The invention provides a method of generating an iPSC utilizing agents that antagonize a cell specific gene or upregulate expression or activity of a nuclear reprogramming gene, as well as a method of screening for such agents.