The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2016
Filed:
Sep. 07, 2012
Applicants:
Stephen J. Doxsey, Sterling, MA (US);
Tse-chun Kuo, Worcester, MA (US);
Chun-ting Chen, Worcester, MA (US);
Inventors:
Stephen J. Doxsey, Sterling, MA (US);
Tse-Chun Kuo, Worcester, MA (US);
Chun-Ting Chen, Worcester, MA (US);
Assignee:
University of Massachusetts, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/86 (2006.01); A61K 38/00 (2006.01); C07K 16/18 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
C07K 16/18 (2013.01); C07K 14/47 (2013.01); C07K 2317/31 (2013.01);
Abstract
The number of midbody derivatives in a cell may be modulated by modulating autophagy induced by NBR1. Exemplary methods include modulating the amount or activity of NBR1 in the cell, potentiating or inhibiting binding between NBR1 and Cep55 in the cell, or modulating the amount of Cep55 in the cell. These methods can be used in the treatment of cancers or in methods of reprogramming cells.