The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2016
Filed:
May. 22, 2013
Applicant:
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Washington, DC (US);
Inventors:
Dennis J. Kopecko, Silver Spring, MD (US);
Manuel Osorio, Bethesda, MD (US);
Monica R. Foote, North Potomac, MD (US);
Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 39/112 (2006.01); C07K 14/24 (2006.01); A61K 39/02 (2006.01);
U.S. Cl.
CPC ...
C07K 14/24 (2013.01); A61K 39/0291 (2013.01); A61K 39/00 (2013.01); A61K 2039/523 (2013.01); C07K 2319/036 (2013.01); C07K 2319/40 (2013.01);
Abstract
Described herein is the generation of a plasmid construct for expression of aF1-V fusion protein. In the disclosed plasmid, the F1-V fusion protein coding sequence is operably linked to thehtrA promoter, and is fused in-frame to theHlyA secretion signal sequence. Also described isserovar Typhi strain Ty21a containing the F1-V fusion protein expression plasmid, such as for use as an oral vaccine against plague.