The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2016
Filed:
Dec. 22, 2011
Brian Robert Miller, San Diego, CA (US);
Scott Glaser, San Diego, CA (US);
Justin Caravella, Cambridge, MA (US);
Susan Foley, Milford, MA (US);
Xiaoping Hronowski, Bedford, MA (US);
Tigran Aivazian, San Diego, CA (US);
Brian Robert Miller, San Diego, CA (US);
Scott Glaser, San Diego, CA (US);
Justin Caravella, Cambridge, MA (US);
Susan Foley, Milford, MA (US);
Xiaoping Hronowski, Bedford, MA (US);
Tigran Aivazian, San Diego, CA (US);
Biogen MA Inc., Cambridge, MA (US);
Abstract
The invention is based, at least in part, on the finding that linker peptides which lack the amino acid sequence GSG reduce or eliminate the addition of posttranslational modifications to the polypeptides which comprise them. More specifically, the novel linker peptides disclosed herein reduce the ability of enzymes to link carbohydrate adducts to polypeptides comprising these linker peptides, e.g., reduce the ability of xylosyltransferase to link xylose to polypeptides. These novel linker peptides, molecules comprising same, and methods of their use are described.