The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2016
Filed:
Oct. 11, 2012
The Hong Kong University of Science and Technology, Hong Kong, CN;
Benzhong Tang, Hong Kong, CN;
Ka Ming Ng, Hong Kong, CN;
Qian Luo, Singapore, SG;
Yong Yu, Hong Kong, CN;
Yuning Hong, Hong Kong, CN;
Jianzhao Liu, Hong Kong, CN;
Sijie Chen, Hong Kong, CN;
Wing Yip Lam, Hong Kong, CN;
THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY, Kowloon, HK;
Abstract
Fluorescent bioprobes comprising luminogen formed nanoparticles comprising luminogens with aggregation-induced emission (AIE) properties, which can be used for long-term cell tracking. The luminogens are nonemissive in organic solution but become highly emissive when aggregated in aqueous solution. The fluorescent molecules can readily pass through cell membranes, stain only the cell cytoplasm, and form highly emissive nanoaggregates in aqueous media without any obvious cytoxicity in the living cells. Furthermore, the molecules can be retained inside the cells without noticeable leakage to the outside. Therefore, these AIE-based compounds can be used as selective and cell-compatible fluroescent bioprobes for long-term live cell tracking and imaging.