The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2016
Filed:
Jun. 27, 2012
Tong-shuang LI, Burnaby, CA;
Ernest Mceachern, Burnaby, CA;
David Vocadlo, Burnaby, CA;
Yuanxi Zhou, Burnaby, CA;
Yongbao Zhu, Burnaby, CA;
Harold Selnick, West Point, PA (US);
Tong-Shuang Li, Burnaby, CA;
Ernest McEachern, Burnaby, CA;
David Vocadlo, Burnaby, CA;
Yuanxi Zhou, Burnaby, CA;
Yongbao Zhu, Burnaby, CA;
Harold Selnick, West Point, PA (US);
Alectos Therapeutics Inc., Burnaby, CA;
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
The invention provides compounds with enhanced permeability for selectively inhibiting glycosidases, prodrugs of the compounds, and pharmaceutical compositions including the compounds or prodrugs of the compounds. The invention also provides methods of treating diseases and disorders related to deficiency or overexpression of O-GlcNAcase, accumulation or deficiency of O-GlcNAc.