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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9409884 B1

PDFFull Text
Date of Patent:
Aug. 09, 2016

Filed:

Jan. 31, 2013

5- or 6-substituted benzofuran-2-carboxamide compounds and methods for using them

Applicant:

Rigel Pharmaceuticals, Inc., South San Francisco, CA (US);

Inventors:

Dane Goff, Redwood City, CA (US);

Donald Payan, Hillsborough, CA (US);

David Carroll, San Francisco, CA (US);

Simon Shaw, Oakland, CA (US);

Hitoshi Yasumichi, Brisbane, CA (US);

Assignee:

Rigel Pharmaceuticals, Inc., South San Francisco, CA (US);

Attorneys:

McDonnell Boehnen Hulbert & Berghoff LLP

Travis Young

Primary Examiner:

Celia Chang

Int. Cl.
CPC ...
C07D 401/14 (2006.01); A61K 31/453 (2006.01); A61K 31/454 (2006.01); A61K 31/4545 (2006.01); A61K 31/4709 (2006.01); A61K 31/4725 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 409/14 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 487/08 (2006.01); C07D 211/46 (2006.01); C07D 211/58 (2006.01); C07D 211/98 (2006.01); C12N 9/12 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61K 31/453 (2013.01); A61K 31/454 (2013.01); A61K 31/4545 (2013.01); A61K 31/4709 (2013.01); A61K 31/4725 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); C07D 211/46 (2013.01); C07D 211/58 (2013.01); C07D 211/98 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 487/08 (2013.01); C12N 9/12 (2013.01); C12Y 207/11031 (2013.01);
Abstract

The disclosure relates particularly to certain carboxamide, sulfonamide and amine compounds and pharmaceutical compositions thereof, and to methods of treating and ameliorating disorders and conditions related to the adiponectin pathway, sphingolipid metabolism, oxidative stress, mitochondrial dysfunction, free radical damage and metabolic inefficiency, among others. In certain embodiments, the compounds have the structures (I-1), (2-I) and (3-I) in which the variables are as described herein.

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