The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2016
Filed:
Oct. 22, 2015
Applicant:
Elobix Ab, Gothenburg, SE;
Inventors:
Martin Bohlin, Johanneshov, SE;
Erica Tjerneld, Enskede, SE;
Andreas Vestermark, Stockholm, SE;
Ingvar Ymen, Saltsjo-boo, SE;
Assignee:
Elobix AB, Gothenburg, SE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 281/10 (2006.01); C07D 281/02 (2006.01);
U.S. Cl.
CPC ...
C07D 281/02 (2013.01); C07D 281/10 (2013.01);
Abstract
The present invention relates to crystal modifications of N-{(2R)-2-[({[3,3-dibutyl-7-(methyl-thio)-1,1-dioxido-5-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-8-yl]oxy}acetyl)amino]-2-phenylethanolyl}glycine (elobixibat), more specifically crystal modifications I, IV, MeOH-1, EtOH-1, 1-PrOH-1 and 2-PrOH-1. The invention also relates to a process for the preparation of these crystal modifications and to a pharmaceutical composition comprising crystal modification IV.