The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2016
Filed:
Aug. 08, 2013
Mitsubishi Tanabe Pharma Corporation, Osaka-shi, Osaka, JP;
Tomoyuki Okabe, Osaka, JP;
Takeshi Hamada, Osaka, JP;
Kaori Tomikawa, Osaka, JP;
Yukie Okamoto, Osaka, JP;
Toru Iijima, Osaka, JP;
Hidenori Akatsuka, Osaka, JP;
Kenichi Toyama, Osaka, JP;
Atsushi Moroda, Osaka, JP;
Yoshihiro Sugiura, Osaka, JP;
MITSUBISHI TANABE PHARMA CORPORATION, Osaka-Shi, JP;
Abstract
The present invention provides an industrially advantageous method for producing a 1,4-benzoxazine compound useful as a medicine while avoiding safety and health risks. Specifically, the present invention provides a method for producing a 1,4-benzoxazine compound [A], which comprises the three steps in the following scheme, namely, a step of converting the amino group at 7-position in a compound [a] into a dimesylamino group, a step of coupling a compound [b] with a boronic acid compound, and a step of converting the 7-position in a compound [c] into a monomesylamino group. In the above scheme, Ms is a methanesulfonyl group, and each of R' and R″ is a hydrogen atom etc.