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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9409322 B1

PDFFull Text
Date of Patent:
Aug. 09, 2016

Filed:

Mar. 11, 2013

Single step polymerization of covalently bound multilayer matrices

Applicant:

The Regents of the University of California, Oakland, CA (US);

Inventors:

Adah Almutairi, La Jolla, CA (US);

Yogesh Ner, McAllen, TX (US);

Jerome Karpiak, San Diego, CA (US);

Jose Morachis, San Diego, CA (US);

Assignee:

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);

Attorneys:

Eleanor Musick

Musick Davis LLP

Primary Examiner:

Robert J Grun

Int. Cl.
CPC ...
B29C 39/12 (2006.01); A61L 27/52 (2006.01); A61L 27/16 (2006.01); A61L 27/18 (2006.01); A61L 27/26 (2006.01); A61L 27/38 (2006.01); A61L 27/50 (2006.01); A61L 27/54 (2006.01); A61L 27/56 (2006.01); B29C 67/00 (2006.01);
U.S. Cl.
CPC ...
B29C 39/123 (2013.01); A61L 27/16 (2013.01); A61L 27/18 (2013.01); A61L 27/26 (2013.01); A61L 27/38 (2013.01); A61L 27/50 (2013.01); A61L 27/52 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); A61L 2300/252 (2013.01); B29C 67/0066 (2013.01); B29C 67/0085 (2013.01); B29C 67/0092 (2013.01);
Abstract

A method is provided for forming complex tissue using density gradient multilayer polymerization (DGMP) to form strong hydrogels with smooth transitions between layers. The multicompartment hydrogel is formed by co-dissolving a polymer precurser with a constituent in multiple solvent fractions to a create prepolymer solutions with different densities, layering the prepolymer solutions on top of each other from high to low solvent density, and irradiating the prepolymer solutions to form a polymer. The hydrogels may be used as biomimetic matrices.

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