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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9408926 B1

PDFFull Text
Date of Patent:
Aug. 09, 2016

Filed:

Nov. 20, 2013

Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy

Applicant:

Bracco Suisse S.a., Manno, CH;

Inventors:

Christophe Arbogast, Viuz-en-Sallaz, FR;

Philippe Bussat, Pers-Jussy, FR;

Hong (Helen) Fan, Shanghai, CN;

Sudha Khurana, Santa Clara, CA (US);

Karen E. Linder, Kingston, NJ (US);

Edmund R. Marinelli, Tucson, AZ (US);

Palaniappa Nanjappan, Princeton, NJ (US);

Adrian D. Nunn, Lambertville, NJ (US);

Radhakrishna K. Pillai, Cranbury, NJ (US);

Sibylle Pochon, Troinex, CH;

Kondareddiar Ramalingam, Stockbridge, GA (US);

Ajay Shrivastava, Princeton, NJ (US);

Bo Song, Princeton, NJ (US);

Rolf E. Swenson, Princeton, NJ (US);

Mathew A. Von Wronski, Geneva, CH;

Feng Yan, Grand-Lancy, CH;

Assignee:

Bracco Suisse S.A., Manno, CH;

Attorney:

Pearl Cohen Zedek Latzer Baratz LLP

Primary Examiner:

Anand Desai

Int. Cl.
CPC ...
C07K 14/00 (2006.01); A61K 49/22 (2006.01); A61K 51/08 (2006.01); C07K 7/08 (2006.01); C07K 14/52 (2006.01); C07K 14/71 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 49/221 (2013.01); A61K 49/223 (2013.01); A61K 51/088 (2013.01); C07K 7/08 (2013.01); C07K 14/001 (2013.01); C07K 14/52 (2013.01); C07K 14/71 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01);
Abstract

The present invention provides polypeptides, peptide dimers, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a K<1 μM), and dimer and multimeric constructs comprising these polypeptides, particularly contrast agents. Also provided are methods for monitoring and evaluating the therapeutic effectiveness of treatment protocols for diseases associated with angiogenesis or endothelial cell hyperproliferation, such as cancer, using contrast agents of the invention.

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