The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 09, 2016

Filed:

Apr. 28, 2011
Applicants:

Takeshi Kuboyama, Tokyo, JP;

Tomohiro Era, Tokyo, JP;

Tomoyuki Naoi, Tokyo, JP;

Inventors:

Takeshi Kuboyama, Tokyo, JP;

Tomohiro Era, Tokyo, JP;

Tomoyuki Naoi, Tokyo, JP;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/16 (2006.01); A61K 47/18 (2006.01); A61K 47/22 (2006.01); C07C 217/08 (2006.01); C07D 211/58 (2006.01); C07C 219/06 (2006.01); C07C 237/22 (2006.01); C07D 491/056 (2006.01); C07C 217/28 (2006.01); C07C 219/08 (2006.01); C07D 207/08 (2006.01); C07D 207/12 (2006.01); A61K 9/00 (2006.01); A61K 9/127 (2006.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 47/16 (2013.01); A61K 9/0019 (2013.01); A61K 9/1272 (2013.01); A61K 47/18 (2013.01); A61K 47/186 (2013.01); A61K 47/22 (2013.01); C07C 217/08 (2013.01); C07C 217/28 (2013.01); C07C 219/06 (2013.01); C07C 219/08 (2013.01); C07C 237/22 (2013.01); C07D 207/08 (2013.01); C07D 207/12 (2013.01); C07D 211/58 (2013.01); C07D 491/056 (2013.01); C12N 15/113 (2013.01); C12N 2310/14 (2013.01); C12N 2320/30 (2013.01);
Abstract

The present invention provides a cationic lipid, which allow nucleic acids to be easily introduced into cells, represented by formula (I) (wherein: Rand Rare, the same or different, alkenyl, etc, and Xand Xare hydrogen atoms, or are combined together to form a single bond or alkylene, and Xis absent or is alkyl, etc, Y is absent or anion, a and b are, the same or different, 0 to 3, and Lis a single bond, etc, Ris alkyl, etc, Land Lare —O—, —CO—O— or —O—CO—), a composition comprising the cationic lipid and a nucleic acid, and a method for introducing a nucleic acid into a cell by using the composition comprising the cationic lipid and the nucleic acid, and the like.


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