The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2016
Filed:
Dec. 07, 2007
Shanthi Adimoolam, Santa Clara, CA (US);
Joseph J. Buggy, Mountain View, CA (US);
Darren Magda, Cupertino, CA (US);
Richard Miller, Portola Valley, CA (US);
Shanthi Adimoolam, Santa Clara, CA (US);
Joseph J. Buggy, Mountain View, CA (US);
Darren Magda, Cupertino, CA (US);
Richard Miller, Portola Valley, CA (US);
Pharmacyclics LLC, Sunnyvale, CA (US);
Abstract
Provided herein are methods for using at least one histone deacetylase inhibitor to decrease cellular DNA repair activity, methods for monitoring the decrease of cellular DNA repair activity using at least one biomarker, methods of treating cancer by using at least one histone deacetylase inhibitor to decrease cellular DNA repair activity in combination therapy, methods of combination therapy where at least one histone deacetylase inhibitor interferes with a DNA repairing mechanism involving RAD51, methods for predicting a induction time period between a first administration of at least one histone deacetylase inhibitor and a second administration of at least one other therapeutic treatment, and pharmaceutical compositions for combination therapy.