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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9403892 B1

PDFFull Text
Expired
Date of Patent:
Aug. 02, 2016

Filed:

Jan. 27, 2014

Therapeutic trail fusion protein and preparation and use thereof

Applicant:

Magellan Pharma Co. Ltd., Nanjing, CN;

Inventors:

Bing Zhou, Yantai, CN;

Yu Zhou, Yantai, CN;

Jing Jiang, Yantai, CN;

Assignee:

MAGELLAN PHARMA CO. LTD., Nanjing, CN;

Attorneys:

Jun He Law Offices P.C.

Jay Z. Zhang

Primary Examiner:

Bridget E Bunner

Int. Cl.
CPC ...
C07K 14/52 (2006.01); A61K 38/17 (2006.01); A61K 38/19 (2006.01); C12P 21/02 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C07K 14/705 (2006.01); C12N 15/63 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/52 (2013.01); C07K 14/70575 (2013.01); A61K 38/00 (2013.01); A61K 38/17 (2013.01); A61K 38/19 (2013.01); A61K 38/191 (2013.01); C07K 2319/73 (2013.01); C12N 5/10 (2013.01); C12N 15/63 (2013.01); C12P 21/02 (2013.01);
Abstract

This invention relates to the biotechnology area, and provides a kind of TRAIL chimeric protein, DNA sequence encoding this chimeric protein, vectors comprising this DNA, host cells or transgenic animals that contain one of the vectors, and preparation methods for the said chimeric protein and its applications. The said TRAIL fusion protein from the N to C terminal comprises human leucine zipper sequence, human TRAIL protein, human TRAIL extracellular domain or a fragment thereof. The chimeric protein has significantly enhanced stability, prolonged half-life in animals, increased efficacy and thus has broad application future.

Find Patent Forward Citations

Zhou, Bing. (2016). Therapeutic trail fusion protein and preparation and use thereof (U.S. Patent No. 9403892). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9403892

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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