The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 02, 2016

Filed:

Dec. 02, 2014
Applicant:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Inventors:

Alejandro Crespo, Edison, NJ (US);

Ping Lan, Dayton, NJ (US);

Rudrajit Mal, Edison, NJ (US);

Anthony Ogawa, Mountainside, NJ (US);

Hong Shen, Shanghai, CN;

Peter J. Sinclair, Doylestown, PA (US);

Zhongxiang Sun, Edison, NJ (US);

Ellen K. Vande Bunte, Hawthorne, NJ (US);

Zhicai Wu, Montvale, NJ (US);

Kun Liu, Boston, MA (US);

Robert J. DeVita, Westfield, NJ (US);

Dong-Ming Shen, Edison, NJ (US);

Min Shu, Greenbrook, NJ (US);

John Qiang Tan, Westfield, NJ (US);

Changhe Qi, Shanghai, CN;

Yuguang Wang, Shanghai, CN;

Richard Beresis, Shanghai, CN;

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 413/06 (2006.01); C07D 231/56 (2006.01); A61K 31/404 (2006.01); A61K 31/416 (2006.01); C07D 403/06 (2006.01); C07D 209/08 (2006.01); C07D 209/10 (2006.01); A61K 31/405 (2006.01); A61K 31/4196 (2006.01); A61K 31/722 (2006.01); A61K 31/4245 (2006.01); A61K 45/06 (2006.01); C07D 403/04 (2006.01); C07D 405/06 (2006.01); A61K 31/4045 (2006.01); A61K 31/422 (2006.01);
U.S. Cl.
CPC ...
C07D 413/06 (2013.01); A61K 31/404 (2013.01); A61K 31/405 (2013.01); A61K 31/4045 (2013.01); A61K 31/416 (2013.01); A61K 31/4196 (2013.01); A61K 31/422 (2013.01); A61K 31/4245 (2013.01); A61K 45/06 (2013.01); C07D 209/08 (2013.01); C07D 209/10 (2013.01); C07D 231/56 (2013.01); C07D 403/04 (2013.01); C07D 403/06 (2013.01); C07D 405/06 (2013.01);
Abstract

The present invention is directed to compounds of the Formula I as well as pharmaceutically acceptable salts thereof, that are useful for treating aldosterone-mediated diseases. The invention furthermore relates to processes for preparing compounds of the Formula I, to their use for the therapy and prophylaxis of the abovementioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical compositions which comprise compounds of the Formula I.


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