The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2016
Filed:
Feb. 23, 2009
Michael Eissenstat, Frederick, MD (US);
Dehui Duan, Frederick, MD (US);
Jihye Kang, Gaithersburg, MD (US);
Michael Eissenstat, Frederick, MD (US);
Dehui Duan, Frederick, MD (US);
Jihye Kang, Gaithersburg, MD (US);
SEQUOIA PHARMACEUTICALS, INC., Gaithersburg, MD (US);
Abstract
Benzofuran-containing amino acid compounds are provided that are potent inhibitors of cytochrome P450 (CYP) enzymes. The compounds have the general structure where at least one of R, R, R, R, R, and Ris —S(O)—(CH)-(benzofuranyl), —(CH)—N(R)(—SO-benzofuranyl), —C(O)—(CH)-(benzofuranyl), —(CH)—N(R)(C(═O)-(benzofuranyl), or C-Calkylene-(benzofuranyl). Pharmaceutical compositions containing the inhibitors are provided and these compositions can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 enzymes.