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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9403776 B1

PDFFull Text
Date of Patent:
Aug. 02, 2016

Filed:

Jun. 13, 2014

Aryl- and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin

Applicants:

Albany Molecular Research, Inc., Albany, NY (US);

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

Bruce F. Molino, Slingerlands, NY (US);

Shuang Liu, Schenectady, NY (US);

Aruna Sambandam, Cary, NC (US);

Peter R. Guzzo, Niskayuna, NY (US);

Min Hu, Schenectady, NY (US);

Congxiang Zha, Schenectady, NY (US);

Kassoum Nacro, Albany, NY (US);

David D. Manning, Duanesburg, NY (US);

Matthew L. Isherwood, Delmar, NY (US);

Kristen N. Ryan, Clifton Park, NY (US);

Wenge Cui, Clifton Park, NY (US);

Richard E. Olson, Orange, CT (US);

Assignee:

Albany Molecular Research, Inc., Albany, NY (US);

Attorney:

LeClairRyan, a Professional Corporation

Primary Examiner:

Brenda Coleman

Int. Cl.
CPC ...
C07D 403/04 (2006.01); C07D 223/16 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 409/04 (2006.01); C07D 409/14 (2006.01); C07D 413/04 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01);
U.S. Cl.
CPC ...
C07D 223/16 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 409/04 (2013.01); C07D 409/14 (2013.01); C07D 413/04 (2013.01); C07D 413/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01);
Abstract

The compounds of the present invention are represented by the following aryl- and heteroaryl-substituted tetrahydrobenzazepine and dihydrobenzazapine derivatives having formulae I(A-E) and formula (II): where the carbon atom designated * is in the R or S configuration, and the substituents X and R-Rare as defined herein.

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