The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2016
Filed:
Nov. 12, 2015
David Hook, Rheinfelden, CH;
Bernard Riss, Huningue, FR;
Daniel Kaufmann, Battwil, CH;
Matthias Napp, Loerrach, DE;
Erhard Bappert, Basel, CH;
Philippe Polleux, Riehen, CH;
Jonathan Medlock, Cambridge, GB;
Antonio Zanotti-gerosa, Cambridge, GB;
David Hook, Rheinfelden, CH;
Bernard Riss, Huningue, FR;
Daniel Kaufmann, Battwil, CH;
Matthias Napp, Loerrach, DE;
Erhard Bappert, Basel, CH;
Philippe Polleux, Riehen, CH;
Jonathan Medlock, Cambridge, GB;
Antonio Zanotti-Gerosa, Cambridge, GB;
NOVARTIS AG, Basel, CH;
Abstract
The invention relates to a new process for producing NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone. In detail, the new processes, according to the present invention, are ultimately related to the synthesis of intermediates to prepare the above NEP inhibitors, namely compounds according to formula (1), or salt thereof, wherein R1 and R2 are, independently of each other, hydrogen or a nitrogen protecting group, and R3 is a carboxyl group or an ester group, preferably carboxyl group or alkyl ester.