The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2016
Filed:
Oct. 24, 2013
Applicant:
GE Healthcare As, Oslo, NO;
Inventor:
Torfinn Haaland, Lindesnes Fabrikker, NO;
Assignee:
GE Healthcare AS, Nycoveien, NO;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 237/46 (2006.01); A61K 49/04 (2006.01); C07C 231/12 (2006.01); C07C 231/14 (2006.01);
U.S. Cl.
CPC ...
C07C 237/46 (2013.01); A61K 49/0438 (2013.01); C07C 231/12 (2013.01); C07C 231/14 (2013.01);
Abstract
The present invention relates to a process for the preparation of iodinated X-ray contrast agents and in particular to key intermediates thereof. It particularly relates to an improved process for preparation of 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide (Compound A) or N,N′-bis(2,3-dihydroxypropyl)-5-formamido-2,4,6-triiodoisophthalamide (Compound C), which are intermediates in the industrial preparation of non-ionic X-ray contrast agents. More particularly the invention provides a process for deacylation of the acylated hydroxyl groups of an intermediate compound of Compound A and Compound C.