The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 02, 2016

Filed:

Apr. 05, 2010
Applicants:

S. Munir Alam, Durham, NC (US);

Barton F. Haynes, Durham, NC (US);

Moses D. Sekaran, Durham, NC (US);

Georgia Tomaras, Durham, NC (US);

Xiaoying Shen, Durham, NC (US);

Inventors:

S. Munir Alam, Durham, NC (US);

Barton F. Haynes, Durham, NC (US);

Moses D. Sekaran, Durham, NC (US);

Georgia Tomaras, Durham, NC (US);

Xiaoying Shen, Durham, NC (US);

Assignee:

DUKE UNIVERSITY, Durham, NC (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/385 (2006.01); A61K 38/21 (2006.01); A61P 31/18 (2006.01); A61K 9/127 (2006.01); A61K 47/48 (2006.01); A61K 39/21 (2006.01); A61K 39/12 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48815 (2013.01); A61K 38/212 (2013.01); A61K 39/12 (2013.01); A61K 39/21 (2013.01); A61K 47/4833 (2013.01); A61K 9/1272 (2013.01); A61K 2039/545 (2013.01); A61K 2039/55511 (2013.01); A61K 2039/55555 (2013.01); A61K 2039/55561 (2013.01); A61K 2039/55572 (2013.01); C12N 2740/16134 (2013.01);
Abstract

The present invention relates in general, to a formulation suitable for use in inducing anti-HIV-1 antibodies, and, in particular, to a formulation comprising Toll Like Receptor (TLR) agonists with HIV-1 gp41 membrane proximal external region (MPER) peptide-liposome conjugates for induction of broadly reactive anti-HIV-1 antibodies. The invention also relates to methods of inducing neutralizing anti-HIV-1 antibodies using such formulations.


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