The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2016
Filed:
Sep. 29, 2015
Applicant:
Purdue Research Foundation, West Lafayette, IN (US);
Inventors:
Mark S. Cushman, West Lafayette, IN (US);
Trung X. Nguyen, West Lafayette, IN (US);
Martin M. Conda-Sheridan, Evanston, IL (US);
Yves George Pommier, Bethesda, MD (US);
Assignee:
Purdue Research Foundation, West Lafayette, IN (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 221/18 (2006.01); A61K 31/473 (2006.01); C07D 401/06 (2006.01); C07D 491/056 (2006.01); A61K 31/4741 (2006.01); A61K 31/5377 (2006.01);
U.S. Cl.
CPC ...
A61K 31/473 (2013.01); A61K 31/4741 (2013.01); A61K 31/5377 (2013.01); C07D 221/18 (2013.01); C07D 401/06 (2013.01); C07D 491/056 (2013.01);
Abstract
The invention described herein pertains to the synthesis and use of certain N-substituted indenoisoquinoline compounds which inhibit the activity Tyrosyl-DNA Phosphodiesterase I (Tdp1) or Topoisomerase I (Top1) or both, or otherwise demonstrate anticancer activity. Also disclosed are novel N-substituted indenoisoquinoline compounds and pharmaceutical compositions comprising the novel N-substituted indenoisoquinoline compounds.