The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2016
Filed:
Apr. 20, 2012
Shingo Matsumoto, Rockville, MD (US);
Robert J. Gillies, Tampa, FL (US);
James B. Mitchell, Damascus, MD (US);
Murali K. Cherukuri, Rockville, MD (US);
Keita Saito, Silver Spring, MD (US);
Shingo Matsumoto, Rockville, MD (US);
Robert J. Gillies, Tampa, FL (US);
James B. Mitchell, Damascus, MD (US);
Murali K. Cherukuri, Rockville, MD (US);
Keita Saito, Silver Spring, MD (US);
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, Washington, DC (US);
H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC., Tampa, FL (US);
Abstract
The identification of pOlowering agents as transient hypoxia-inducers is disclosed herein. Provided is a method of enhancing the efficacy of a hypoxia-sensitive agent in a subject, by administering to the subject a therapeutically effective amount of the hypoxia-sensitive agent and a therapeutically effective amount of a pOlowering agent. Methods of treating a subject with a tumor, by administering to the subject a therapeutically effective amount of a pOlowering agent and a therapeutically effective amount of a hypoxia-sensitive agent are also disclosed.