The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2016
Filed:
Dec. 13, 2013
Applicant:
Sichuan University, Chengdu, CN;
Inventors:
Rui Li, Chengdu, CN;
Yuquan Wei, Chengdu, CN;
Assignee:
Sichuan University, Chengdu, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/10 (2006.01); A61K 31/167 (2006.01); A61K 31/18 (2006.01); A61K 31/495 (2006.01); A61K 31/5375 (2006.01); A61K 31/683 (2006.01); A61K 31/255 (2006.01); C07C 323/62 (2006.01); C07C 317/48 (2006.01); C07C 317/50 (2006.01); C07C 323/63 (2006.01); C07C 237/44 (2006.01); C07F 9/40 (2006.01);
U.S. Cl.
CPC ...
A61K 31/167 (2013.01); A61K 31/18 (2013.01); A61K 31/255 (2013.01); A61K 31/495 (2013.01); A61K 31/5375 (2013.01); A61K 31/683 (2013.01); C07C 237/44 (2013.01); C07C 317/48 (2013.01); C07C 317/50 (2013.01); C07C 323/62 (2013.01); C07C 323/63 (2013.01); C07F 9/4056 (2013.01);
Abstract
The present invention relates to the technical field of chemically synthesized drugs, in particular to an anti-HIV drug or prodrug and preparation method and uses thereof. The compound or prodrug compound of the present invention has a structural formula as represented by formula I. The compounds have anti-HIV-1 and anti-HIV-2 virus activity, and have a C8166 therapeutic index as high as 2081.59 and an H9 therapeutic index as high as 303.03. Furthermore, the compounds have high solubility up to 1290-2845.5 μg/ml in an aqueous solution, and can be formulated into an oral formulation.